Multimode Microplate Reader YR07005

The YR07005 is a microplate reading system equipped with a continuous monochromator from 200 to 1000 nm and a photomultiplier tube (PMT) for ultra-sensitive readings. Its compatibility with the ultra-micro u-Nano plate allows quantification of samples from 2 to 4 µL without the need for prior dilutions. It incorporates interchangeable filter modules via QR codes, multidirectional shaking, and an optional automatic injector system with spill protection. With Ethernet, FTP, and USB connectivity, this instrument ensures smooth integration into biomedical data networks.

Advanced Design and Technology

• 5 Mode Versatility: Adds Fluorescence Polarization (FP) to standard modes (ABS, FL, LUM, TRF), ideal for studying protein-protein and ligand-receptor interactions.

• High Sensitivity Optics: Monochromator from 200 to 1000 nm with 1 nm steps for absorbance and independent filter-based optics with dichroic mirrors for high sensitivity assays.

• Optimized Photomultiplier Tube (PMT): Maximizes detection of weak luminescent and fluorescent signals, reducing crosstalk between wells (crosstalk ≤0.005%).

• Ultra-Micro u-Nano Plate: Allows simultaneous quantification of up to 16 or 96 nucleic acid and protein samples with volumes as low as 2 to 4 μL.

• Integrable Lum-Check Microplate: Allows quick verification and standardization of the luminescence module to ensure continuous and reliable calibration.

Frequently Asked Questions (FAQ)

• What is the Fluorescence Polarization (FP) mode used for? It is ideal for studying intermolecular interactions such as drug binding to receptors, DNA/protein interactions, and tyrosine kinase screening.

• What plate formats are compatible? Supports standard plates of 6, 12, 24, 48, 96, and 384 wells, PCR plates, and the ultra-micro u-Nano plate.

• Can custom protocols be saved? Yes, the ReaderIt-II software allows configuring and storing multiple analytical methods, managing data via FTP, USB, or Ethernet export.

Advantages and Disadvantages

Key Advantages:

• Maximum Analytical Coverage: The 5 detection modes in a single device eliminate the need for multiple instruments in the laboratory.

• Extreme Detection: Achieves sensitivity limits of up to 1 pM in fluorescence and ≤15 amol/well in luminescence.

• Long-Lasting Xenon Lamp: Capable of performing up to $10^9$ flashes with a continuous spectral scanning time of less than 15 seconds.

Disadvantages / Considerations:

• Space and Weight Requirement: Being a complete analytical device of 33 kg, it requires a stable and level laboratory table.

• Technical Training: The advanced use of the FP mode and the configuration of dual injectors requires training from laboratory personnel.

Product Use in the Field and Recommendations

• Ideal Applications: Pharmaceutical R&D centers, molecular biology laboratories, oncology research, immunoassays, and drug discovery.

• Recommended Maintenance: Use ABS and Lum-Check optical performance validation plates for periodic operational qualifications.

• Operation Recommendation: Scan the QR code of the filter modules for automatic loading of measurement parameters and avoid manual configuration errors.